SPRAVATO® Nasal Spray for Treatment-Resistant Depression
If you've tried multiple antidepressants without relief, SPRAVATO® may offer a new path forward. Mind Rejuvenation is proud to provide SPRAVATO® (esketamine) CIII nasal spray, the first FDA-approved ketamine-derived treatment covered by insurance for treatment-resistant depression (TRD).
- SPRAVATO® nasal spray in Tulsa, OK
- FDA-approved, insurance-covered treatment-resistant depression care
- Tulsa's first SPRAVATO® provider, administered under clinical supervision
A nasal spray for treatment-resistant depression
SPRAVATO® (esketamine) is a prescription nasal spray for adults with Major Depressive Disorder (MDD) who have not responded to at least two other antidepressants. It is the first FDA-approved ketamine-derived treatment covered by insurance for treatment-resistant depression.
It is also approved for adults experiencing suicidal thoughts or behaviors in the context of depression. SPRAVATO® is not a pain reliever or anesthetic, and it is not for use in children.
Unlike traditional antidepressants, SPRAVATO® works differently — targeting NMDA receptors in the brain to help restore chemical balance. Administered under medical supervision, it is part of a comprehensive treatment plan that includes ongoing support and monitoring. It is not intended for use in children or as a substitute for hospitalization when needed.
When standard treatments fall short
Treatment-resistant depression affects millions of people who struggle to find relief through conventional medications. Symptoms may persist despite trying multiple therapies, leaving individuals feeling helpless or discouraged.
SPRAVATO® is a breakthrough option that offers relief and a restored sense of self for those who've felt hopeless or frustrated in their mental health journey. It's not just about symptom relief — it's about reclaiming a sense of possibility.
How SPRAVATO® works
Unlike traditional antidepressants, SPRAVATO® targets glutamate pathways in the brain to help restore chemical balance. Many patients report feeling better within hours or days rather than weeks.
Administered in-office
Patients self-administer the nasal spray under direct clinical supervision in our office.
Monitored sessions
Each visit includes post-dose observation to ensure your safety and comfort.
Gradual improvement
Many patients report feeling better within hours or days, not weeks.
Integrated care
SPRAVATO® is always used alongside oral antidepressants and ongoing therapy support.
Why patients choose SPRAVATO®
Fast-acting relief
Rapid symptom relief for treatment-resistant depression.
Approved and trusted
FDA-approved for adults with suicidal ideation and Major Depressive Disorder.
Insurance-friendly access
Covered by many insurance plans — we guide you through every step.
Safe, supportive environment
Administered in a calm, supervised clinical setting at our Tulsa office.
Local, personalized care
Personalized care from Tulsa's first SPRAVATO® provider.
Your treatment, step by step
Your first visit includes a full consultation and medical screening. If SPRAVATO® is right for you, we'll guide you through each step — from insurance approval to your first dose. Sessions typically last two hours and include post-treatment monitoring.
Referral and screening
A referral from your mental health provider is required. Your first visit includes a full consultation and medical screening.
In-office dosing
You self-administer the nasal spray in a calm, closely monitored setting under clinical supervision.
Monitored session
Each visit lasts about two hours and includes observation after your dose to ensure safety and comfort.
A regular schedule
Treatment is usually twice weekly for the first four weeks, then weekly, adjusted to how you respond.
What to expect with SPRAVATO®
Discover how SPRAVATO® has helped others reclaim their lives
Real patients share how SPRAVATO® therapy helped them when other treatments had not.
SPRAVATO® patient storiesOften covered by insurance
SPRAVATO® is covered by many insurance plans. If it is right for you, we guide you through every step, from insurance approval to your first dose, so cost and paperwork never stand between you and care.
Want to discuss alternatives? Ask your care team about Ketamine IV therapy, another treatment-resistant depression option we offer.
Learn about Ketamine IV therapyStart your healing journey today
Whether you're ready to book your first visit or simply have questions about our treatments, we're here to help. Fill out our Contact Form and a member of our team will reach out shortly.
Every step you take toward wellness matters — and we're honored to walk it with you.
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